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Ming Qi,PhD.FACMG
Is currently the Professor and the founding Director of Center for Genetic & Genomic Medicine at Zhejiang University, a Principal Investigator of Beijing Genome Institute, Chinese Academy of Sciences and full Professor at University of Rochester Medical School.? He received his MS from Fudan University, Shanghai in 1985 mentored by Dr. C.C. Tan, the “Father of Genetics at China”.He was successful in the national competition to be a student of the CUSBEA (China-USA Biochemistry / Molecular Biology) Program and received his PhD from University of Pittsburgh. Dr. Qi did his postdoctoral training in Dr.Stan McKnight’s Lab, University of Washington from 1991-1994.? He successfully created
  multiple PKA mouse models by gene knock-out,published in PNAS, Cell, etc. He has four publications co-authored with Dr. Eric Kandel, the 2000 Nobel Laureate. Dr. Qi had his ABMG postdoc fellowship in Molecular Genetics with Dr. Peter Byers at University of Washington from 1994-1998 and was certified in clinical molecular genetics by American Board of Medical Genetics in 1999. He involved in the initiation and conduction of the identification of the JAG gene responsible for Alagille syndrome, published in Nature Genetics. From the end of 1998, he has been an assistant professor at University of Rochester School of Medicine, Department of Pathology & Laboratory Medicine. He created and directed the clinical molecular genetics laboratory for the International Long QT Syndrome Registry. Recently, he expends the research and clinical service scope to other genetic channelopathies as a core facility. From April 2006 to August 2006, he has been Visiting Associate Geneticist, Consultant and Acting Director of Lab Mol Medicine, Harvard Medical School -Partners Healthcare Center for Genetics and Genomics. ??He is co-PIs of three active NIH grants.?? He is a fellow of American College of Medical Genetics, HUGO Lecturer and CAP molecular lab inspector.
 

List of Work Experiences:

1991-1994    Post-doctoral fellow: Molecular Biology (gene knock-out). Advisors: Drs. Rejean Idzerda /Stanley McKnight, Dept of Pharmacology, University of Washington, Seattle, WA.

1994-1998    American Board of Medical Genetics Training Fellow: clinical molecular genetics; Advisor: Dr. Peter Byers, Depts of Medicine Pathology, Univ of WashingtonSeattle, WA.

1998-now     Assistant Professor, Depts of Pathology Laboratory Medicine, Cardiology Research
Center, University of Rochester Medical Center

1998-now     Visiting Professor, Human Genome Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China

2004.7-now   Professor, Beijing Genome Institute, Chinese Academy of Sciences, Beijing, China

2005.10-now   Professor and founding Director, Zhejiang University-Adinovo Center for Genetic and Genomic Medicine. ( Formerly known as Center for Genetic and Genomic Medicine, Zhejiang University)

2006.4-8     Visiting Associate Geneticist, Consultant, Acting Director of Lab Mol Medicine, Harvard Medical School-Partners Healthcare Center for Genetics and Genomics

 

Representative Publications
1. Qi, M., B.J.Hamilton and D. DeFranco (1989),v-mos Oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors. Molecular Endocrinology, 3: 1279-1288. (Cover article).

2. Qi, M., Stasenko,L.J., and D. DeFranco (1990),Glucocorticoid receptors bound by the hormone antagonist RU486 are resistant to v-mos mediated desensitization. Molecular Endocrinology, 4:455-464.

3. Hsu, S., Qi, M., and D. DeFranco (1992), Cell cycle regulation of glucocorticoid receptor function, EMBO J, 11:3457-3468.

4. Huang Y-Y., Kandel, E., Varshavsky, L., Brandon, E., Qi, M., Idzerda, R., McKnight, G., and R. Bourtchouladze (1995), A genetic test of the effects of PKA mutations on Mossy fiber and its relationship to spatial and contextual learning. Cell. 83: 1211-1222.

5. Qi, M., Zhou, M., Skalhegg, B., Brandon, E., Kandel, K.,McKnight, G. and R. Idzerda (1996), Impaired hippocampal plasticity in PKA-Cb-1 mutant mice. Proc. Natl. Acad.Sci.USA. 93: 1571-1576.

6. Li, L., Krantz, I., Deng, Y., Genin, A., Banta, A., Collins, C., Qi, M., Trask, B.,Kuo, W., Cochran, J., Costa, T., Pierpont,M., Rand, E., Piccoli, D., Hood, L., and N. Spinner (1997). Alagille syndrome is caused by mutations human Jagged1, which encodes a ligand for Notch 1. Nat. Genet. 16: 243.

7. Hamilton, S., Loose,M.,Qi, M., Levey, A., Hille, B., McKnight, G.,Idzerda, R., and N. Nathanson (1997). Disruptionof the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc. Natl. Acad.Sci.USA., 94: 13311-13316.

8. Qi, M., and P. Byers (1998), Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the Menkes protein and produces the occipital horn syndrome. Hum. Mol. Genet. 7: 465-469.

9. Ning, L.; A. Moss, W. Zareba, J. Robinson, S. Rosero, D. Ryan, M. Qi (2003) Denaturing high-performance liquid chromatography reliably detects ion channel mutations in Long QT syndrome. Genetic Testing, 7:249-253.

10. HUANG T, M. QI (2005) Report ? 21st century medical genetic and genomic medicine in China. J Zhejiang Univ SCIENCE B ?6(12):1223-1226

11. MOTULSKY A, M. QI (2006) Pharmacogenetics and ecogenetics. J Zhejiang Univ SCIENCE B; 7(2): 169-170

12. Jenny B. Hobbs, Derick R. Peterson, Arthur J. Moss, Scott McNitt, Wojciech Zareba, Ilan Goldenberg, Ming Qi, Jennifer L. Robinson, Andrew J. Sauer, Michael J. Ackerman, Jesaia Benhorin, Elizabeth S. Kaufman, Emanuela H. Locati, Carlo Napolitano, Silvia G. Priori, Jeffrey A. Towbin, G. Michael Vincent, Li Zhang. (2006) RISK OF ABORTED CARDIAC ARREST OR SUDDEN CARDIAC DEATH DURING ADOLESCENCE IN THE LONG-QT SYNDROME 。 JAMA; 296:1249-1254。